Synthesis of New Pyrroline Nitroxides with Ethynyl Functional Group

Synthesis and Electron Spin Relaxation of Tetracarboxylate Pyrroline Nitroxides

We report the design, synthesis, and electron spin relaxation properties of hydrophilic tetracarboxylate ester pyrroline nitroxides 1 and 2, which serve as models in the search for new spin labels for DEER distance measurement at room temperature. The nitroxides are designed to have the methyl groups further away from the N-O spin site to decrease the inequivalent couplings of the unpaired elec...

Synthesis of Unnatural Amino Acids Functionalized with Sterically Shielded Pyrroline Nitroxides

A series of unnatural amino acids functionalized with sterically shielded pyrroline nitroxides were synthesized. Their reduction by ascorbate/glutathione indicates that L-cysteine functionalized with gem-diethylpyrroline nitroxide is reduced at the slowest rate and is comparable to that measured for the most resistant to reduction pyrroline and pyrrolidine nitroxides.

Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors.

A series of new Tacrine analogs modified with nitroxides or pre-nitroxides on 9-amino group via methylene or piperazine spacers were synthesized; the nitroxide or its precursors were incorporated into the Tacrine scaffold. The new compounds were tested for their hydroxyl radical and peroxyl radical scavenging ability, acetylcholinesterase inhibitor activity and protection against Aβ-induced cyt...

3-Ethynyl-2,2,5,5-tetra­methyl-1-oxyl-3-pyrroline

The five-membered ring of the title compound, C(10)H(14)NO, is almost planar [mean deviation from best plane = 0.006 (1) Å]. The N-O bond is in the plane of the five-membered ring. The mol-ecule is positioned about a pseudo-mirror plane at y = 0.375. In the crystal, mol-ecules are connected by inter-molecular C-H⋯O contacts into layers parallel to (010).

Synthesis and Utilization of α-Substituted Nitroxides